出生体重增加超过4000克与没有糖尿病的出生中不良结果有关
Alyssa R Hersh1, Katherine C Fitch2, Bharti Garg1
1Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, United States.
American journal of perinatology
|October 14, 2025
概括
高出生体重,超过4000克,显著增加了对母亲和新生儿不良结果的风险. 这些风险被孕产妇肥胖和过度的妊娠体重增加所放大,即使没有糖尿病.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 出生的体重是胎儿健康的关键指标.
- 宏观症 (高出生体重) 与不良的产科并发症有关.
- 像BMI和GWG这样的孕产妇因素对宏观体质相关风险的影响需要进一步研究.
研究的目的:
- 评估增加出生体重 (超过4000克) 和不良产科结果之间的关联.
- 探索孕前母亲的BMI和孕期体重增加对这些风险的影响.
- 为了分析这些协会在出生不复杂的糖尿病.
主要方法:
- 在美国对单个,非异常活产 (2012-2021) 的回顾性队列研究.
- 排除患有糖尿病或出生体重<3,000克的婴儿.
- 分为出生体重类别 (3,000-3,999g,4,000-4,499g,4,500-4,999g,≥5,000g) 的分层,并根据妊娠前的BMI和GWG进行分析.
主要成果:
- 分析了超过2300万例分娩;较高的出生体重与剖腹产,输血,子宫切除,ICU入院和关节损伤的风险增加有关.
- 新生儿不良后果也随着出生体重的增加而增加.
- 分层显示,高出生体重类别的风险增加,特别是在母亲肥胖或过度GWG的情况下.
结论:
- 超过4000克的出生体重与不良周产期结果的风险逐渐增加有关,独立于糖尿病.
- 孕产妇肥胖和过度的GWG加剧了与高出生体重相关的风险.
- 这些发现强调了监测和管理与胎儿生长相关的孕产妇体重因素的重要性.
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