3D打印战略的进展,以开发有效的可植入药物输送系统:最近的应用和机遇
Kieran Lau1, Hien A Tran1, Renjian Tan2
1School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia; Sydney Biomanufacturing Incubator, University of Sydney, Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Advanced drug delivery reviews
|October 14, 2025
概括
3D打印使先进的植入式药物输送系统能够实现精确,持续的治疗释放. 这篇评论探讨了3D打印技术.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 增材制造 增材制造 增材制造
背景情况:
- 植入式药物输送系统比全身药物输送系统具有优势,包括精确的定位和持续的治疗释放.
- 目前的局限性包括在复杂的生物环境中导航和控制药物释放动力学方面的挑战.
- 可植入结构的物理架构对于调节生物材料的治疗释放至关重要.
研究的目的:
- 批判性地评估3D打印技术在设计先进的可植入药物输送系统中的应用.
- 分析目前用于控制和持续释放多种药物的3D打印策略的有效性.
- 确定下一代可植入药物输送系统的挑战和机遇.
主要方法:
- 对生物材料开发的增材制造 (3D打印) 技术的审查.
- 对区域特定的药物负载和层次结构的3D打印结构设计的分析.
- 对治疗药物和组织工程中的应用进行控制和持续释放的策略的评估.
主要成果:
- 3D打印为在可植入设备中创建复杂的几何形状和层次结构提供了多功能,具有成本效益的方法.
- 通过定制的3D打印设计,可以实现特定区域的药物加载和多种治疗药物的受控释放.
- 现有的策略显示了治疗治疗和组织工程应用的潜力.
结论:
- 3D打印是开发复杂的可植入药物输送系统的关键技术,可以加强对药物释放的控制.
- 对优化3D打印参数和材料选择的进一步研究可以打开新的治疗可能性.
- 应对当前的挑战将为下一代可植入系统铺平道路,其效率提高,应用范围更广.
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