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结构指导设计的小说5-HT2A部分激动剂作为具有抗抑郁作用的迷幻类似物

Rongyan Li1,2, Haohan Yan3, Yujin Chen1,2

  • 1iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.

Journal of medicinal chemistry
|October 14, 2025
PubMed
概括

新的非幻觉性血清素2A (5-HT2A) 部分激动剂在抑郁症治疗中表现有前途. 化合物28c在小鼠中表现出抗抑郁作用,为SSRI提供了潜在的替代品.

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