在健康的男性中,在睡眠期间的动态大脑自调节伴随着间歇性缺氧
Andrew E Beaudin1,2,3, Andrew J Prsa1,3, Patrick J Hanly3,4,5
1Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Journal of applied physiology (Bethesda, Md. : 1985)
|October 14, 2025
概括
动态大脑自调节 (dCA) 在健康男性的非快速眼动 (NREM) 睡眠期间仍然有效. 间歇性缺氧 (IH) 暴露在睡眠期间,类似于阻塞性睡眠呼吸暂停,没有改变NREM睡眠dCA.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 心血管生理学心血管生理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是中风风险因素,可能是由于间歇性缺氧 (IH) 引起的大脑自我调节的损害.
- 人类在睡眠期间的大脑自调节还不清楚,睡眠期间IH暴露对这一过程的影响仍然不清楚.
研究的目的:
- 在健康的男性中调查清醒和非快速眼动 (NREM) 睡眠期间的动态大脑自调节 (dCA).
- 为了确定NREM睡眠期间的IH暴露是否会改变dCA.
- 为了在睡眠期间的急性和长时间IH暴露期间比较dCA.
主要方法:
- 对先前收集的关于大脑血流 (中脑动脉速度),平均动脉压 (MAP) 和二氧化碳潮尾部分压力的数据进行二次分析.
- 使用转移函数分析 (增益,相位,连贯性) 来量化dCA在正常和IH条件下的清醒和NREM睡眠期间.
- 清醒和睡眠之间的dCA测量和normoxic和IH睡眠条件之间的比较,包括急性与长时间的IH暴露.
主要成果:
- 与清醒相比,NREM睡眠期间的大脑血流和MAP变异性较低.
- 在清醒和NREM睡眠之间,dCA测量 (增益,阶段,连贯性) 是相似的.
- 在正常睡眠和IH伴随睡眠期间,dCA的测量没有显著差异,也没有在急性和长期IH暴露之间有显著差异.
结论:
- 动态大脑自调节是有效的,并在健康的年轻男性中在NREM睡眠阶段2/3期间保持.
- 在NREM睡眠期间约2小时的IH暴露,模仿中度至重度的OSA,不会影响dCA.
- 睡眠期间脑血流减少和血压变化可能会导致持续的dCA.
相关概念视频
Autoregulation of Blood Flow
7.5K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
7.5K
Sleep-Wake Cycles
2.7K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K
Physiological Control of Respiration
5.8K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
5.8K
Neural Regulation of Blood Pressure
6.9K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
6.9K


