对急性损伤 (AKI) 和慢性病 (CKD) 诊断的生物传感器创新
Nurain Najihah Alias1, Asad Masood2, Poh Choon Ooi1
1Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, Bangi 43600, Malaysia.
ACS applied bio materials
|October 14, 2025
概括
新的生物传感器可以快速检测病生物标志物. 这些先进的设备改善了急性损伤 (AKI) 和慢性病 (CKD) 的诊断,使得早期治疗和更好的患者结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 临床诊断 临床诊断 临床诊断
背景情况:
- 功能衰竭,包括急性损伤 (AKI) 和慢性病 (CKD),由于功能受损,给健康带来了重大挑战.
- 目前用于病的诊断方法往往缺乏必要的敏感性和特异性,需要改进检测策略.
- 病的复杂性强调了对先进生物标志物和快速诊断工具的迫切需要.
研究的目的:
- 审查用于诊断病的生物传感器技术的最新进展.
- 探索各种生物传感器平台的应用,包括基于电化学,等离子体和纳米粒子的系统,用于检测AKI和CKD生物标志物.
- 突出生物传感器在为及时干预提供护理点 (POC) 诊断方面的作用.
主要方法:
- 专注于电化学,光学和压电式生物传感器设计和制造.
- 讨论生物识别元素和转导机制.
- 在开发非侵入性生物传感器诊断方面探索材料科学.
主要成果:
- 使用先进表面化学的生物传感器在识别和量化新兴病生物标志物方面表现有前途.
- 基于电化学,等离子体和纳米粒子的生物传感器是POC应用的关键平台.
- 优化的生物传感器设计和制造方法提高了对各种诊断需求的有效性.
结论:
- 生物传感器在早期检测和治疗功能衰竭方面取得了重大进展.
- 开发敏感和特定的生物传感器对于改善AKI和CKD患者的治疗结果至关重要.
- 未来的研究方向包括进一步优化生物传感器材料和对脏疾病的非侵入性诊断能力.
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