上层结肠体投射驱动多巴胺神经元活动和运动,但不是价值
Carli L Poisson1,2,3, Izzabella K Green1,2,3,4, Gretchen M Stemmler1,2
1Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455.
概括
上层结核 (SC) 影响腹膜区域 (VTA) 和黑质体 (SNc) 中的多巴胺 (DA) 神经元,以控制头部转向用于感觉运动学习,而不是奖励处理.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 多巴胺通路是多巴胺的通路.
背景情况:
- 动物整合感官信息的生存,多巴胺 (DA) 神经元在腹膜区域 (VTA) 和黑色物质 (SNc) 关键的提示结果关联.
- 感官输入到DA通路的整合仍然不太清楚,尽管上层结核 (SC) 接收直接的视觉输入,并可能将信息传递给DA神经元.
研究的目的:
- 在大鼠中研究SC和VTA/SNc之间的解剖学和功能联系.
- 确定SC投射到VTA/SNc在行为,奖励和感觉运动学习中的作用.
主要方法:
- 解剖学追踪将SC投影映射到VTA/SNc.
- 在体内电生理学记录SC神经元活动及其对VTA/SNc神经元的影响.
- 在帕夫洛夫条件和强化范式中,对SC→VTA/SNc通路和DA神经元接受SC输入的光遗传学刺激.
主要成果:
- 在VTA/SNc中,SC神经元密集地向DA和GABA神经元投射并激发它们.
- SC→VTA/SNc通路的激活不支持初级强化或产生位置偏好/避开.
- 刺激SC→VTA/SNc神经元主要引起头部转动,重复刺激时强度增加.
结论:
- 对VTA/SNc的SC投射调节DA神经元活动以控制头部运动,有助于传感运动学习和注意力切换.
- 这种电路优先参与运动反应而不是奖励处理,突出了它在指导行为中的独特作用.
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