咖啡摄入量和血压:一种门德尔的随机研究
Jiwen Zhong1, Sichao Huang2, Shaohong Dong3
1Department of Critical Care Medicine, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong 519000, China.
经常喝咖啡可能会导致血压降低 (BP). 这项孟德尔随机化研究发现,咖啡摄入显著降低了心缩和心缩血压,这表明对经常喝咖啡的人有保护作用.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传流行病学遗传流行病学
- 营养流行病学 营养流行病学
背景情况:
- 观察性研究将咖啡消费与降低血压联系起来.
- 咖啡摄入量和血压之间的因果关系仍然不确定.
- 门德尔随机化 (MR) 可以使用遗传变异来调查因果关系.
研究的目的:
- 为了确定咖啡消费对血压 (BP) 的因果关系.
- 为了利用一个强大的MR设计与独立的,大规模的数据集.
主要方法:
- 采用了两样 MR 设计.
- 从英国生物银行GWAS元分析 (N=428,860) 中确定了咖啡消费的遗传变异.
- 利用ICBP和英国血压研究的BP数据;用反变量加权 (IVW) 和灵敏度分析 (MR-PRESSO,加权中位数) 分析.
主要成果:
- 咖啡消费显著降低了缩血压 (SBP) (β=-1.92,p=0.028) 和腹缩血压 (DBP) (β=-1.34,p=0.004).
- 结果在所有灵敏度分析中一致,包括MR-PRESSO和加权中位数.
- 多变量MR证实了对SBP和DBP的类似因果作用.
结论:
- 定期饮用咖啡与降低血压有因果关系.
- 咖啡的摄入量可能会提供一种保护性心血管益处.
- 咖啡消费代表了BP管理的潜在有益的生活方式选择.
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