慢性鼻炎患者的初级抗体缺乏:在进行生物疗法之前,呼吁进行免疫学评估
Anita García Petersen1, Kasra Zainali-Gill2, Carsten Schade Larsen3
1Ear Nose and Throat Department, Lillebaelt Hospital Vejle, University Hospital of Southern Denmark, Vejle, Denmark.
概括
慢性鼻炎 (CRS) 通常与初级抗体缺乏症 (PAD) 相关,这是一个可治疗的疾病. 在CRS患者中测试免疫球蛋白水平可以识别PAD,在考虑使用生物药物之前改善治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
背景情况:
- 慢性鼻炎 (CRS) 显著影响生活质量,在患有主抗体缺乏症 (PAD) 的患者中更为常见.
- 尽管有有效的CRS治疗方法,但PAD的诊断不足,当它是PAD的症状时.
研究的目的:
- 为了调查患有CRS的成年人中PAD的患病率.
- 评估CRS患者免疫球蛋白检测的诊断效用.
主要方法:
- 一项前性队列研究包括138名成年CRS患者.
- 评估了患者的低血球蛋白血和对肺炎球菌多糖体疫苗的反应.
- 根据临床标准诊断出PAD,包括常见可变免疫缺陷 (CVID) 和IgA/IgG亚类缺陷.
主要成果:
- 21%的患者患有低胺球蛋白血症.
- 11%的患者表现出疫苗反应不足,诊断为特异性抗体缺乏症 (SPAD) 尚不清楚.
- 四名患者 (3%) 符合PAD的标准 (一个CVID,一个IgA缺乏,两个IgG子类缺乏). 没有临床因素预测PAD.
结论:
- 在考虑使用生物疗法之前,建议对CRS患者进行免疫球蛋白检测.
- PAD是一个未被认可的,可治疗的耐火性CRS的原因.
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