甲酸暴露与慢性病中心血管疾病风险增加有关:来自NHANES和网络毒理学分析的证据
Gewenhan Chen1, Yan Luo1, Xiaoyin Wu1
1Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Renal failure
|October 14, 2025
概括
暴露于塑料中常见的酸盐化学物质与慢性病患者心血管疾病 (CVD) 风险增加有关. 这种关联在多种先进的统计模型中是一致的,突出显示了CKD患者潜在的健康问题.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 慢性病 (CKD) 是一个重要的全球健康问题.
- 心血管疾病 (CVD) 是CKD患者的主要死亡原因.
- 甲酸盐暴露很普遍,并与各种健康问题有关.
研究的目的:
- 调查甲酸盐暴露与CKD患者自我报告的心血管疾病之间的关联.
- 分析作为单个代谢物和复杂混合物的甲酸盐暴露.
- 确定潜在的生物途径和治疗点,涉及甲酸诱导的CVD在CKD.
主要方法:
- 从国家健康和营养检查调查 (NHANES,2003-2018) 中对2,227名参与者的横截面分析.
- 后勤回归来评估个别的甲酸代谢物风险.
- 先进的混合分析包括权重量子和 (WQS),量子G计算 (qgcomp) 和贝叶斯内核机器回归 (BKMR) 模型.
- 网络毒理学分析以确定枢纽基因.
主要成果:
- 四种甲酸盐代谢物 (MBP,MEHHP,MEOHP,MECPP) 与心血管疾病风险增加有显著关联.
- 混合物分析模型始终表明,在CKD患者中,甲酸盐混合物和心血管疾病之间存在积极的关联.
- 网络毒理学确定了PPARG,CASP9和CTSS作为关键基因,调解了甲酸盐暴露,CKD和CVD之间的联系.
结论:
- 甲酸暴露与患有CKD的个体的不良心血管结果有关.
- 甲酸盐混合物对CKD患者的心血管健康构成风险.
- 在CKD中,PPARG,CASP9和CTSS可以作为关键调解器和潜在的治疗点,用于甲酸相关心血管疾病.
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