沈康对慢性病的影响:与网络药理学分析相匹配的倾向评分
Xiaocui Wang1,2, Qinxiu Zhang1,2, Enjie Tang3
1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Renal failure
|October 14, 2025
概括
沈 (SK) 在慢性病 (CKD) 患者的使用与末期病风险降低和功能下降速度减缓有关. 这项现实研究表明,SK是CKD管理的有前途的治疗选择.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 沈康 (SK) 是一种广泛用于慢性病 (CKD) 的草药配方.
- 验证SK对CKD结果的长期影响的现实证据有限.
- 这项研究旨在评估SK使用与CKD患者的临床结果之间的关联.
研究的目的:
- 评估沈康 (SK) 对慢性病 (CKD) 患者长期预后的影响.
- 在SK用户和非用户之间比较末期病 (ESRD) 的风险和估计膜过率 (eGFR) 下降的速度.
- 通过网络药理学探索SK作用的潜在机制.
主要方法:
- 从2013年到2023年对CKD门诊患者的一项单一中心的回顾性研究.
- 倾向性得分匹配被用来比较 546 个接受 SK 的患者与对照组.
- 网络药理学分析调查了SK的分子标和途径.
主要成果:
- SK使用与末期病风险明显降低相关 (aHR=0.83,p=0.030).
- 在SK组中,ESRD的累积发病率较低 (p=0.027).
- SK用户的eGFR下降速度明显较慢 (p<0.001),男性患者特别受益.
结论:
- 沈康 (SK) 是改善慢性病 (CKD) 患者临床结果的有希望的治疗选择.
- SK可以通过调节PI3K/AKT和MAPK信号通路并影响血液动力学来发挥其作用.
- 进一步的体内和体外实验验证是有必要的,以证实这些发现.
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