耗尽,新陈代谢,和风险评估的克洛皮多尔在肉
Seong-Hoon Jeong1, Hyeong-Jin Youn1, Ji-Young An1
1Environmental Safety-Assessment Center, Korea Institute of Toxicology (KIT), Jinju, 52834, Republic of Korea.
Scientific reports
|October 14, 2025
概括
肉中的克洛皮多尔残留物迅速耗尽,在3天内低于量化限值. 健康风险评估证实,可食用组织中的残留克洛皮多尔度在所有人口群体中都是安全的.
科学领域:
- 兽医药理学 兽医药理学
- 食品安全 食品安全
- 分析化学 分析化学
背景情况:
- 克洛皮多尔是畜牧业中广泛使用的抗菌剂.
- 可食用组织中的克洛皮多尔残留物可能对人类消费者构成风险.
- 了解克洛皮多尔残留物耗尽和代谢对于食品安全至关重要.
研究的目的:
- 为了研究在肉中放射性标记的 [3H]-clopidol 的残留物耗尽和代谢.
- 确定克洛皮多尔在肝脏,肌肉,脏和脂肪中的度和消除率.
- 评估与可食用组织中的克洛皮多尔残留物相关的人类健康风险.
主要方法:
- 放射性标记的 [3H]-clopidol (25 mg/kg体重) 口服给肉.
- 严格验证分析方法,包括选择性,线性,系统适用性,准确性和精度.
- 使用射电高性能液体染色学 (射电HPLC) 和液体闪光计数 (LSC) 量化克洛皮多尔残留物.
- 使用液体染色学-质谱法 (LC-MS) 识别代谢物.
主要成果:
- 在 (29.22 ± 2.3 毫克/公斤) 和肝 (28.81 ± 2.41 毫克/公斤) 中,在服药6小时后观察到克洛皮多尔残留物最高度.
- 残留物水平显著下降,在3天内在所有研究的组织中低于定量化极限.
- 一个主要的代谢物,3,5-二-2-基甲基-6-甲基-4-ol,在给药6小时后在所有组织中被确定.
- 卫生风险评估表明,残留克洛皮多尔度是安全的消费所有年龄组和性别.
结论:
- 克洛皮多尔在肉中表现出快速耗尽,其残留物在给药后迅速减少.
- 已识别的代谢物存在的度低于原始化合物.
- 该研究为监测克洛皮多尔残留物提供了经过验证的框架,支持在家禽生产中安全使用.
- 可食用组织中的克洛皮多尔残留水平对消费者没有显著的健康风险.
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