在Omicron感染患者口腔真菌微生物群的动态变化
Yarong Ma1, Shanshuo Liu1, Guizhen Zhang1
1Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Scientific reports
|October 14, 2025
概括
在Omicron变种感染和恢复期间,口腔真菌微生物组发生变化. 这项研究确定了关键的真菌标记物,为Omicron变种患者创建了诊断模型.
科学领域:
- 医学真菌学 医学真菌学
- 微生物组研究 微生物组研究
- 传染性疾病 传染性疾病
背景情况:
- 口腔真菌微生物群与各种疾病有关.
- 口腔真菌在Omicron变种感染中的作用仍然未被探索.
研究的目的:
- 调查感染Omicron变种 (PIOV) 的患者口腔真菌微生物群的变化.
- 为了比较PIOV,康复患者 (RP),感染原始SARS-CoV-2菌株 (PIOS) 的患者和健康对照 (HC) 之间的口腔真菌概况.
- 开发一种基于口腔真菌标记物的PIOV诊断模型.
主要方法:
- 963个舌头涂层样本的内部转录间隔器 (ITS) 测序.
- 对口腔真菌多样性和物种组成的比较分析.
- 随机森林模型,用于诊断模型开发的五倍交叉验证.
主要成果:
- 在PIOV恢复期间,口腔真菌的微生态多样性增加.
- 特定的真菌物种,如Zanclospora_jonesii增加,而Saccharomyces_cerevisiae在恢复期间减少.
- 与PIOS相比,PIOV的α多样性明显较低,具有不同的主导物种.
- 一个诊断模型实现了高精度 (99.01%的发现,97.84%的验证).
结论:
- 这项研究提供了第一次大规模阐明口腔真菌微生物群在Omicron变体感染和恢复期间的变化.
- 口腔真菌微生物组的改变可以作为PIOV的非侵入性诊断模型的基础.
相关概念视频
01:29Fungal Group Zygomycota
995
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
995
01:26Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
01:28Fungal Phylum Microsporidia
422
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
422