固体瘤对CAR T细胞疗法的耐药性的微环境调节
Zachary L Lamplugh1,2, Nils Wellhausen2,3,4, Carl H June5,6,7
1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Nature reviews. Immunology
|October 14, 2025
概括
化学抗原受体 (CAR) T细胞疗法在固体瘤中面临挑战,原因是免疫抑制性瘤微环境 (TME). 克服TME障碍的策略对于提高CAR T细胞在癌症治疗中的疗效至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 化学抗原受体 (CAR) T细胞疗法在癌症治疗方面表现有前途.
- 它在固体瘤中的有效性受到免疫抑制瘤微环境 (TME) 的限制.
研究的目的:
- 审查TME如何阻碍固体瘤中CAR T细胞治疗.
- 讨论改善固体瘤CAR T细胞治疗的策略.
主要方法:
- 关于CAR T细胞治疗和TME的当前文献的综述.
- 分析阻碍CAR T细胞功能的TME细胞和非细胞组成部分.
主要成果:
- 通过各种机制,TME损害了CAR T细胞的贩运,功能和持续性.
- 异常的瘤血管结构,密集的细胞外基质,免疫抑制细胞,免疫检查点分子和代谢竞争有助于抵抗.
结论:
- 重编程TME或工程CAR T细胞是提高疗效的潜在策略.
- 克服TME介导的耐药性是成功治疗固体瘤的CAR T细胞治疗的关键.
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