硫化衍生的周血管脂肪组织在血管疾病中的作用
Emma Mitidieri1, Chiara Indolfi1, Vincenzo Brancaleone2
1Department of Pharmacy, School of Medicine and Surgery, Naples, Italy.
Handbook of experimental pharmacology
|October 14, 2025
概括
周血管脂肪组织 (PVAT) 释放硫化 (H2S),这是血管健康的关键因素. 在PVAT中H2S的失调有助于心血管疾病,突出其治疗潜力.
科学领域:
- 血管生物学 血管生物学
- 内分泌学 在内分泌学.
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 周血管脂肪组织 (PVAT) 是一个内分泌器官,对血管平衡至关重要,在健康状态下表现出抗收缩,抗炎和抗氧化性质.
- 病理生理条件可以改变PVAT功能,将其作用转移到促收缩效应,并导致心血管疾病.
- 硫化 (H2S) 被确定为PVAT释放的关键抗收缩因子.
研究的目的:
- 研究PVAT衍生的H2S在血管健康和疾病中的作用.
- 了解PVAT中的H2S生物合成酶如何受到疾病状态的影响.
- 探索调节PVAT衍生的H2S用于预防心血管疾病的治疗潜力.
主要方法:
- 在不同血管床和物种的PVAT中分析H2S生物合成酶表达.
- 研究代谢和心血管疾病对PVAT H2S生产的影响.
- 评估PVAT衍生的H2S对血管功能的近影响.
主要成果:
- 负责H2S生物合成的酶在PVAT中具有差异性表达,并且可以在疾病状态下改变.
- 在PVAT内H2S信号的变化有助于血管功能障碍.
- 由PVAT衍生的H2S在与肥胖相关的血管疾病,高血压和糖尿病中发挥着重要作用.
结论:
- 来自PVAT的H2S是血管度和恒温的关键调节者.
- 在PVAT中H2S生产的失调有助于心血管疾病的发病.
- 准PVAT H2S生物合成是血管疾病的有前途的治疗策略.
相关概念视频
01:30Peripheral Artery Disease I: Introduction
313
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
313
01:29Cholesterol: Significance and Regulation
1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.2K
01:02Hypodermis
7.2K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.2K
01:24Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
01:24Peroxisomes
20.0K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
20.0K