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恶性卵巢:一系列9例病例中的临床病理学和分子特征

Xuxi Yang^1,2, Wanrun Lin³, Lei Qin^1,2

¹Departments of Pathology, The International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.

Virchows Archiv : an international journal of pathology

|October 14, 2025

概括

恶性卵巢瘤 (MSO) 是一种罕见的卵巢瘤. 这项研究验证了世卫组织2022年对MSO的甲状腺瘤分类,显示了与甲状腺癌的组织分子重叠以及保守手术的优异结果.

科学领域:

妇科病理学妇科病理学
内分泌病理学内分泌病理学
分子瘤学分子瘤学

背景情况:

恶性卵巢瘤 (MSO) 是一种罕见的卵巢瘤,需要改进分类和管理策略.
现有的诊断框架可能无法完全捕捉MSO的临床病理和分子细微差别.
了解MSO的组织分子特征对于准确的诊断和风险分层至关重要.

研究的目的:

确定恶性卵巢的临床病理学和分子特征.
评估世界卫生组织 (WHO) 2022年甲状腺瘤分类对MSO亚型和管理的适用性.
为了将组织分子发现与MSO患者的临床结果相关联.

主要方法:

分析了9个MSO病例,使用综合组织病理学和免疫组织化学 (IHC).
针对性下一代测序 (NGS) 用于MSO瘤的分子概况.
根据世卫组织2022年甲状腺瘤标准对MSO亚型的分类.

主要成果:

许多MSO病例包括乳头甲状腺癌 (PTC),毛囊甲状腺癌 (FTC),细胞 (Hürthle细胞) 癌 (OCA) 和分化高度甲状腺癌 (DHGTC).
分子分析显示,在三个病例中出现NRAS/HRAS突变,在一个PTC中出现BRAF突变,在四个病例中出现EIF1AX/PTEN/KMT2C/BRCA1突变.
世卫组织2022年分类将瘤分为RAS类和BRAF类组,没有检测到TERT促进子突变或RET/PTC融合.

结论:

恶性卵巢瘤表现出明显的组织分子重叠与原发性甲状腺癌.
世卫组织2022年甲状腺瘤分类框架已被验证用于MSO的诊断亚型和风险分层.
保守的手术管理与低级MSO病例的优异结果有关,支持其实用性.

关键词:

恶性卵巢 (Struma ovarii) 是一种恶性卵巢.管理管理管理管理分子分类的分子分类.卵巢三瘤卵巢三瘤

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