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一项关于D-二聚体对急性动脉封闭性介质缺血病患者死亡率预测价值的回顾性研究

Yaliu Yang¹, Peng Liu¹, Ruilong Gao¹

¹Department of Cardiology, China-Japan Friendship Hospital, No.2 East Yinghua Road, Chaoyang District, Beijing, 10029, China.

BMC gastroenterology

|October 14, 2025

概括

急性动脉封闭性介质缺血症 (AOMI) 的死亡率很高. 基线血清D-二聚物水平可以预测AOMI患者的短期和长期死亡率,有助于早期风险分层.

科学领域:

血管外科血管外科
医学生物标志物医学生物标志物
预测研究预测研究

背景情况:

急性动脉封闭性介质缺血症 (AOMI) 是一种具有高死亡率的关键血管紧急情况.
由于缺乏早期预后工具,需要可访问的生物标志物,以便及时管理.
这项研究评估了AOMI患者的死亡结果和基线血清D-二次体的预后值.

研究的目的:

在被诊断患有AOMI的患者中,评估基线血清D-二聚物水平的预后效用.
评估D-二次体水平与AOMI中的死亡结果之间的关联.
在AOMI中确定D-二次体对短期和长期死亡率的预测准确性.

主要方法:

从2010年1月到2024年8月,对61名AOMI患者进行了回顾性队列研究.
在诊断后24小时内测量血清D-二聚物水平.
多变量考克斯回归和ROC曲线分析评估了D-二分体对死亡率的预测值.

主要成果:

整体30天死亡率为47.5%,一年死亡率为54.1%.
升高的D-二次数独立预测了30天 (HR 1.158) 和1年死亡率 (HR 1.277).
ROC分析显示出强大的预测准确性 (AUC为30天0.850,1年死亡率为0.837).

结论:

AOMI仍然是一个具有严重预后的疾病.
基线血清D-二聚体是AOMI中死亡率的显著独立预测因子.
在AOMI中,D-二聚物可以作为早期风险分层和临床决策的实用生物标志物.

关键词:

急性动脉封闭性介肠缺血症是什么意思 D-二聚子 D-二聚子预后预后预测预测

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