委内瑞拉艾滋病毒研究现状:系统审查
Jesús A Morgado1,2, María G Medina1,2, Rafael N Guevara3
1Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolívar, Venezuela.
BMC infectious diseases
|October 14, 2025
概括
由于不稳定,委内瑞拉的艾滋病毒研究表现不佳,阻碍了实现联合国艾滋病规划署目标的进展. 存在重大知识差距,特别是在流行病学和治疗疗效方面,需要有针对性的举措.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 委内瑞拉的医疗保健基础设施受到经济和政治不稳定的影响.
- 这种不稳定性影响了传染病管理,包括艾滋病毒.
- 联合国艾滋病毒/艾滋病联合计划署 (UNAIDS) 95-95-95目标的进展受到阻碍,艾滋病毒研究受到阻碍.
研究的目的:
- 描述委内瑞拉艾滋病毒研究的情况.
- 确定过去二十年的研究缺口和优先事项.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 在PubMed,Scopus和Biblioteca Virtual en Salud数据库中搜索了2003年1月至2023年8月间发表的文章.
- 包括有关委内瑞拉艾滋病毒的原始研究文章;不包括评论,社论,叙事评论和案例报告.
主要成果:
- 在683个已识别的产品中,有101个符合纳入标准.
- 研究集中在临床表现 (50%),流行病学 (14%),以及抗逆转录病毒疗法 (ART) /儿科 (11%).
- 在怀孕期间对艾滋病毒的研究有限 (4%);在委内瑞拉移民中对艾滋病毒的研究增加.
- 确定了感染流行病学,ART疗效/耐药性,临床方面以及怀孕期间的艾滋病毒方面的重大知识差距.
结论:
- 审查强调了委内瑞拉艾滋病毒研究中的重大研究缺口和可能过时的优先事项.
- 有限的科学生产阻碍了准确评估实现联合国艾滋病规划署目标的进展.
- 有针对性的研究举措和增加投资对于改善委内瑞拉艾滋病管理至关重要.
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