胎盘和血清阿斯素水平与怀孕和自发早产之间可能存在的关系
Cihan Gul1, Kazım Uckan2, Salih Cibuk3
1Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Van Yüzüncü Yıl University, Van, 65080, Turkey. c.gul56@gmail.com.
BMC pregnancy and childbirth
|October 14, 2025
概括
母体血清和胎盘中阿斯素水平升高与早产有关. 较高的阿斯素表明怀孕时间较短,出生体重较低,这表明它有可能成为早产预测生物标志物.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 阿斯普拉辛是一种新发现的阿迪波金,参与各种生理和病理过程.
- 过早分娩仍然是全球新生儿发病率和死亡率的主要原因.
- 确定可靠的生物标志物来预测早产,对于及时干预至关重要.
研究的目的:
- 调查母体血清和胎盘阿斯素度与早产之间的关联.
- 评估阿斯素作为预测早产生物标志物的潜力.
主要方法:
- 这是一项涉及75名参与者的横截面研究,分为早期早产,晚期早产,预产和非怀孕的对照组.
- 使用酶相关免疫吸收检测 (ELISA) 量化血清和胎盘阿斯素水平.
- 相关性分析和接收器运行特征 (ROC) 曲线分析以评估关联和预测值.
主要成果:
- 显著更高的血清和胎盘阿斯素水平被观察到与早产的妇女比到期的分娩 (p <0.01).
- 阿斯素水平与妊娠年龄 (r = -0.647至 -0.716,p < 0.01) 和新生儿出生体重 (r = -0.683,p < 0.01) 有着强烈的反向相关性.
- ROC分析表明,阿斯素在预测早产时的潜在切断值.
结论:
- 增加的母体血清和胎盘asprosin度显著与早产有关.
- 阿斯素水平与妊娠时间和婴儿出生体重有反向关系.
- 亚斯素作为早产的潜在预测生物标志物具有前景,值得对其潜在机制进行进一步研究.
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