对患有急性血源性骨髓炎的儿童深静脉血栓的风险因素分析
Ronghao Zhao1, Jiale Guo1, Hanwen Zhang1
1Department of Orthopedics, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Nanlishi Road 56, Xicheng District, Beijing, 100045, China.
BMC musculoskeletal disorders
|October 14, 2025
概括
在患有急性血源性骨髓炎 (AHO) 的儿童中,年龄,峰值D-二次体水平和并发性肺炎是深静脉血栓 (DVT) 的独立危险因素. 一个预测模型显示了儿童AHO患者早期DVT风险预警的良好性能.
科学领域:
- 儿童传染病 儿童传染病
- 血液学 血液学 血液学
- 血管医学是一种血管医学.
背景情况:
- 急性血源性骨髓炎 (AHO) 是儿童严重的骨感染.
- 深静脉血栓症 (DVT) 是AHO的潜在并发症,导致发病率增加.
- 了解儿科AHO中DVT的风险因素对于及时干预至关重要.
研究的目的:
- 调查儿童AHO和DVT之间的相关性.
- 为了确定AHO次要的DVT的独立风险因素.
- 开发一个对儿科AHO的DVT风险的预测模型.
主要方法:
- 儿科AHO患者 (2017-2023) 的临床数据的回顾性分析.
- 使用单变量和二进制逻辑回归对患有和没有DVT的患者进行比较.
- 使用适度测试和ROC曲线评估预测模型性能.
主要成果:
- 单变量分析显示DVT与年龄,CRP,ESR,PCT,D-二次体,CRP正常化时间,肺炎,重症监护室停留,骨髓炎严重程度 (劳森得分) 和大腿部卷入之间存在关联.
- 二元逻辑回归确定年龄 (OR=1.248),D-二次数 (OR=1.600) 和并发性肺炎 (OR=4.921) 作为DVT的独立风险因素.
- 预测模型表现出良好的匹配 (R2=0.449) 和强大的预测性能 (AUC=0.895).
结论:
- 年龄,峰值D-二次体和并发性肺炎是儿科AHO中DVT的关键独立风险因素.
- 开发的预测模型为AHO患者提供DVT风险的早期预警.
- 需要进一步的多中心验证;该模型可以指导DVT查和管理决策.
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