在临床前AD试验中招募和保留:学术和非学术网站之间的比较
Marina Ritchie1, Kedir Hussen2, Oliver Langford2
1Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, USA. ritchiem@usc.edu.
Alzheimer's research & therapy
|October 15, 2025
概括
学术和非学术场所在阿尔茨海默病试验招募和参与者特征上有所不同. 非学术领域的网站由于撤回同意或失去后续工作而出现更高的学率.
科学领域:
- 临床试验 临床试验
- 神经退行性疾病 神经退行性疾病
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 阿尔茨海默病 (AD) 临床试验涉及多种不同类型的场所,包括学术和非学术环境.
- 关于网站类型如何影响AD试验的招聘和保留的研究有限.
研究的目的:
- 在临床前AD试验中,评估学术和非学术场所之间的招聘策略和参与者特征的差异.
- 评估网站类型对参与者保留和停止参与者的原因的影响.
主要方法:
- 利用了无症状AD (A4) 抗粉样蛋白治疗试验的数据,这是一个大型临床前AD研究.
- 在学术和非学术网站之间比较招聘来源,参与者人口统计和临床特征.
- 采用多变量后勤回归来分析保留差异,并根据地点类型检查参与者学原因.
主要成果:
- 学术网站通过媒体和推招募了更多的参与者,而非学术网站更多地依赖内部推和广告.
- 参与者的个人资料有所不同:学术网站注册了患有痴呆症的家庭史和高等教育的人,而非学术网站有更多患有糖尿病史和种族/族群代表不足的参与者.
- 没有观察到总体完成率的显著差异,但非学术网站显示了更高的查和更低的随机化率的趋势. 在非学术场所的参与者更有可能因为同意撤回或失去后续而停止.
结论:
- 在临床前阿尔茨海默病试验中,学术和非学术场所在招募和参与者特征方面存在显著差异.
- 研究人员在设计和进行多站点AD试验时应考虑这些特定场所的因素,以优化试验结果.
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