在患有双极性抑郁症的青少年中,肠道微生物群的重塑和感官情绪功能障碍
Anying Tang1,2,3,4, Yi Chen1, Jiahong Ding5
1Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Journal of translational medicine
|October 15, 2025
概括
青少年双相情感障碍 (BD) 显示出明显的肠道微生物群落,与大脑功能相关,并通过提氨酸治疗改善. 肠道微生物群生物标志物可以准确诊断BD并预测治疗反应.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一种精神病学.
背景情况:
- 青春期是双相情感障碍 (BD) 发病的关键时期.
- 肠道微生物群的干扰与青少年的神经发育问题有关.
- 在青少年BD中描述肠道微生物群对于理解大脑功能障碍至关重要.
研究的目的:
- 在患有BD的青少年中描述肠道微生物群.
- 调查肠道微生物群与青少年BD脑功能障碍之间的相关性.
- 评估奎胺治疗对肠道微生物群的影响及其预测价值.
主要方法:
- 招募了30名患有BD (抑郁情节) 的未经药物治疗的青少年和25名健康对照 (HC).
- 收集的便样本用于BD患者在四周的奎提阿平治疗前和之后的元基因组测序.
- 利用静态功能磁共振成像 (fMRI) 和随机森林模型进行数据分析.
主要成果:
- 与HC相比,青少年BD患者表现出改变的肠道微生物群落,与特定的代谢途径相关.
- 奎胺治疗调节了关键细菌种的丰富性.
- 肠道微生物群生物标志物有效地区分了BD和HC (AUC为91.12%) 并预测了治疗反应 (AUC为91.84%).
- 整合微生物群和神经成像数据提高了预测准确度.
结论:
- 这项研究首次对青少年BD肠道微生物群进行了表征.
- 结合肠道微生物群和大脑功能生物标志物,显示出BD诊断和治疗结果预测的潜力.
- 由于样本大小等研究限制,需要进行进一步的机制研究.
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