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Updated: Jan 15, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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美元和困境:莱纳卡帕维尔的定价,专利,以及通往负担能力的道路

Victor Abiola Adepoju1, Abdulrakib Abdulrahim2

  • 1Department of HIV and Infectious Diseases, Jhpiego Nigeria (An Affiliate of Johns Hopkins University), Abuja, 900911, Nigeria. schrodinga05@yahoo.com.

International journal for equity in health
|October 15, 2025
PubMed
概括

莱纳卡帕维尔 (Lenacapavir) 是一种新的长效艾滋病毒预防注射剂,其预计的市场价格很高,可能会使许多人无法获得该药. 许可协议排除了关键的中等收入国家,引发了全球艾滋病毒预防工作的公平问题.

关键词:
全球健康 全球健康艾滋病毒/艾滋病病毒/艾滋病病毒卫生公平性健康公平性这就是Lenacapavir.药品专利 药品专利 药品专利

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Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
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Drug elimination refers to drug removal from the body, either through urine or bile, by the kidneys or liver, respectively. A pharmacokinetic parameter, drug clearance, measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the drug's concentration in plasma.
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Body:In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
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