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呈现上皮层-介质细胞过渡的癌症表现出一种富含M2巨细胞的瘤免疫微环境
Huang-Chun Lien1,2, Yu-Chia Li2, Ruby Yun-Ju Huang3,4
1Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Breast cancer research : BCR
|October 15, 2025
概括
表皮-介质细胞过渡 (EMT) 驱动一个富含M2巨细胞的瘤微环境 (TME),促进免疫抑制. 这表明向巨细胞和免疫检查点可能会用EMT治疗侵袭性癌症.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 表皮-介质细胞过渡 (EMT) 与免疫抑制性瘤微环境 (TME) 有关.
- 缺乏与EMT和没有EMT配对瘤区域的TME的直接比较.
研究的目的:
- 通过比较配对瘤区域来研究EMT对TME的影响.
- 用于分析具有和没有EMT的转移性乳腺癌 (MpBC) 中的免疫瘤标志物.
主要方法:
- 使用了数字空间分析仪 (DSP) 测定和NanoString nCounter数字分析.
- 分析MPBC的无特殊类型 (NST) 和状癌 (SPS) 组件中的免疫瘤学标志物.
- 免疫组织化学,多重免疫光学,以及M2巨细胞两极分化的体外分析.
主要成果:
- 与NST相比,SPS组件 (EMT对应物) 显示显著丰富的巨细胞标记物.
- 在SPS组件中观察到M2巨细胞表型,细胞因子和基因的丰富.
- 实验室研究证实EMT增强了M2巨细胞两极分化,其中包括CSF1.
结论:
- EMT驱动一个富含M2巨细胞的TME,有助于在各个器官中抑制免疫力.
- 针对巨细胞和免疫检查点的治疗策略显示了EMT驱动癌症的潜力.
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