Jove
Visualize
联系我们

相关概念视频

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

180
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
180
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

212
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
212

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association between neutrophil to high-density lipoprotein cholesterol ratio and 28-day mortality in sepsis patients: Analysis from the MIMIC-IV database.

Medicine·2025
Same author

Two- and many-body physics of ultracold molecules dressed by dual microwave fields.

Nature communications·2025
Same author

Environmental and sociological factors shape sustainable entrepreneurial intentions among Pakistani university students.

Scientific reports·2025
Same author

Bose-Einstein Condensates of Microwave-Shielded Polar Molecules.

Physical review letters·2025
Same author

Ultracold field-linked tetratomic molecules.

Nature·2024
Same author

Early Mammogram Screening's Impact on Early Breast Cancer Detection in Underserved Populations.

Cureus·2023
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 15, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K

肝功能障碍和偏头痛之间的双向因果关系:一个调解的门德尔随机化研究.

Su Yi1, Huirong He2, Lihua Hang1,2

  • 1Department of Anesthesiology, Kunshan Hospital Affiliated to Jiangsu University, Suzhou, China.

Medicine
|October 15, 2025
PubMed
概括

升高的胆红素和酸氨基转移酶 (AST) 基因与偏头痛风险增加有关. 这些肝功能标志物通过大脑结构和肝脏新陈代谢影响偏头痛,突出显示肝脑轴.

关键词:
亚斯巴酸氨基转移酶胆红素是什么意思 胆红素是什么意思肝脏功能障碍 肝脏功能障碍调解调解是指调解的方式.门德尔的随机化是门德尔的随机化偏头痛 偏头痛 偏头痛 偏头痛

更多相关视频

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.6K

相关实验视频

Last Updated: Jan 15, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.6K

科学领域:

  • 神经学 神经学
  • 肝病学 肝病学是一种肝病学.
  • 遗传学 是一个遗传学.
  • 代谢学 代谢学 代谢学

背景情况:

  • 偏头痛是一种致残的神经疾病,可能与肝脏代谢有关.
  • 观察性研究表明胆红素,酸氨基转移酶 (AST) 和偏头痛风险之间存在关联,但因果关系尚不清楚.
  • 混因素需要严格调查肝功能标志物和偏头痛之间的因果关系.

研究的目的:

  • 研究基因预测血清胆红素和AST水平对偏头痛风险的因果关系.
  • 通过大脑结构或肝脏生物标志物探索这些影响的潜在调解途径.
  • 阐明肝脑轴在偏头痛病理生理学的作用.

主要方法:

  • 两个样本的孟德尔随机化 (MR) 框架使用来自IEU OpenGWAS项目的数据.
  • 作为主要分析方法的反变量权重 (IVW),支持MR-Egger和加权中位数方法.
  • 为了确保稳定性和有效性,进行了多重性,异质性和遗漏分析.

主要成果:

  • 基因预测的升高胆红素显著增加了偏头痛风险 (OR=1.055,P=0.003),32%通过皮质厚度进行调解.
  • 基因预测AST升高也增加了偏头痛风险 (OR=1.100,P=0.007),其中12%是由马-氨基转移酶 (GGT) 调解的.
  • bilirubin 和 AST 对偏头痛风险的直接影响很大 (分别为 68% 和 88%).

结论:

  • 血清 bilirubin 和 AST 作为偏头痛的遗传风险因素.
  • 因果作用的部分介于大脑结构变化 (bilirubin) 和肝脏代谢途径 (AST-GGT).
  • 建议对肝功能障碍患者的偏头痛风险进行临床监测,同时研究肝脑轴干预措施.