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系统性炎症反应指数 (SIRI) 预测了维护血液透析患者的死亡率和心血管事件:一项相关研究

Shen Jinwei¹, Mai Weikang², Huang Ying¹

¹Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

|October 15, 2025

概括

高系统炎症反应指数 (SIRI) 水平与维持血液透析 (MHD) 患者的死亡率和心血管事件增加有关. 这项研究强调SIRI是MHD群体不良结果的关键预测因子.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
心脏病学心脏病学
炎症研究炎症研究

背景情况:

维持血液透析 (MHD) 患者经常表现出微型炎症,增加死亡率和心血管事件 (CVEs) 的风险.
系统性炎症反应指数 (SIRI) 是一种具有癌症和心血管疾病预后价值的新型炎症标志物.
有限的研究存在于SIRI与死亡率和CVE的相关性,特别是在MHD患者中.

研究的目的:

调查SIRI与MHD患者全因死亡率和发生的CVE之间的关联.
确定SIRI是否作为该人群中不良结果的独立风险因素.

主要方法:

对275名新入院的MHD患者进行了回顾性队列研究.
根据中位数值将患者分为高SIRI和低SIRI组.
卡普兰-梅尔曲线,多变量后勤回归,以及用于分析的竞争风险模型.

主要成果:

通过受限立方脊柱分析观察到SIRI和全因死亡率/CVEs之间的线性关联.
卡普兰-梅尔曲线和竞争风险模型显示SIRI组之间的结果存在显著差异.
在调整后的Cox模型中,高SIRI独立地与增加全因死亡风险 (OR 3.652) 和新发的CVE (OR 2.224) 相关.

结论:

升高的SIRI水平是MHD患者全因死亡率和CVE的重要独立风险因素.
SIRI可以作为一个有价值的预后标记,用于预测MHD患者的不良事件.

关键词:

所有原因的死亡率.心血管事件的发生.维护血液透析维持血液透析系统性炎症反应指数

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