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全球知识映射和在类风湿性关节炎和外体的融合新兴研究趋势:基于CiteSpace的视觉分析

Zhifeng Zhou^1,2,3, Minghui Hou¹, Jiayi Ling¹

¹General Medical Department, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.

|October 15, 2025

概括

外基因组 (EXOs) 在类风湿性关节炎 (RA) 发病过程中发挥着双重作用. 这项研究绘制了RA中EXO的全球研究,确定了未来治疗开发的关键主题和协作差距.

科学领域:

生物医学科学生物医学科学
免疫学免疫学免疫学
细胞生物学细胞生物学
材料科学材料科学材料科学
人工智能的人工智能

背景情况:

类风湿性关节炎 (RA) 是一种不断增长的自身免疫性疾病,导致持续的突触性炎症和关节破坏.
外体 (EXOs),纳米级囊泡调解细胞间通信,对于调节突微环境至关重要.
在RA的发病过程中,EXO具有双重作用,可能促进或减轻疾病的进展.

研究的目的:

系统地综合RA和外体的跨学科联系的碎片化研究.
分析全球研究趋势,主题演变和RA-EXOs领域的协作网络,使用文献识别分析.
为 RA 治疗开发提供战略主题选择,协作和翻译创新的知识框架.

主要方法:

使用CiteSpace软件进行图书统计分析.
从科学网络核心集合 (2000-2025) 中分析了244份文件.
审查出版物增长,地理分布,主题优先事项和协作网络.

主要成果:

学术成果同比显著增长,超过9723次引用,表明学术影响力不断增长.
中国在出版物方面处于领先地位,伊朗和德国的新兴中心表现出加剧的活动.
关键的研究主题包括EXO的抗炎活性,同胞细胞的代谢重编程和无细胞DNA (cfDNA) 驱动的免疫失调;边境地区涉及工程 EXO 和cfDNA介导的免疫调节.

结论:

国际合作存在,但缺乏跨学科的整合,特别是从材料科学和人工智能.
该研究为RA-EXOs接口提供了第一个全面的知识框架.
确定研究缺口和机会可以指导未来的战略话题选择和下一代RA疗法的转化创新.

关键词:

在CiteSpace中使用CiteSpace.没有细胞的DNA DNA.外基因组是外基因组的组成部分.纤维细胞类同胞细胞类似于纤维细胞的同胞细胞.类风湿性关节炎类风湿性关节炎

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