治疗复发性复发性多发性硬化症的特里弗卢诺米德:来自沙特阿拉伯的经验
Morad Aljinaid1, Osama Khojah2,3,4, Layan Arshad1
1Neuroscience Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Medicine
|October 15, 2025
概括
在沙特阿拉伯,teriflunomide在治疗多发性硬化症 (MS) 中表现出适度的有效性,许多患者没有达到疾病活性的证据. 然而,由于不良影响,特别是脱发而导致的停药率很高.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多发性硬化症 (MS) 是一种慢性免疫媒介炎症疾病,影响中枢神经系统.
- 特里弗卢诺米德是一种FDA批准的口服疾病修饰疗法,用于复发性缓解性MS.
研究的目的:
- 在沙特阿拉伯评估特里弗卢诺米德在MS患者的有效性和耐受性.
- 评估临床复发率,新的MRI病变,并实现没有疾病活性证据 (NEDA-3).
主要方法:
- 一项多中心回顾性研究,涉及38名MS患者,从2016年3月至2020年9月接受了teriflunomide治疗.
- 收集了关于临床复发,脑MRI发现,残疾状态 (EDSS) 和不良反应 (AE) 的数据.
主要成果:
- 63.2%的患者没有发现疾病活性的证据 (NEDA-3).
- 23.7%的人经历了临床复发,26.3%的人出现了新的MRI病变.
- 观察到高停药率为36.8%,主要是由于不良反应 (57.1%的停药),头发变薄/脱发是最常见的副作用 (15.8%).
结论:
- 在沙特阿拉伯人口中,特里弗卢诺米德在控制MS疾病活动方面表现出适度的有效性.
- 较高的副作用率导致了大量的治疗中止,影响了整体耐受性.
- 建议进行进一步的大规模本地研究以验证这些发现.
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