三种口服的诺基诺在老鼠中的组织学,免疫组织化学和生物化学效应的比较

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Turan Yaman¹, Fatih Donmez², Abdulahad Dogan²

¹Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, Turkey.

Drug and chemical toxicology

|October 15, 2025

概括

诺基诺抗生素可以导致雄性大鼠的丸损伤和炎症. 这项研究研究了西普罗夫洛克萨,莱沃弗洛克萨和莫西弗洛克萨对大鼠丸的影响,揭示了潜在的男性生殖毒性.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

诺基诺 (FQs) 是广泛用于人类和兽医的宽谱抗生素.
有关FQs的潜在生殖毒性存在担忧,需要进一步调查.

研究的目的:

评估西普洛素 (CIP),莱沃素 (LVX) 和莫西素 (MXF) 对大鼠丸组织的组织学,免疫组织化学和生物化学影响.
评估这些FQ衍生物对男性生殖健康的时间依赖性影响.

主要方法:

72只雄性Wistar白色老鼠被分为对照组和治疗组 (CIP,LVX,MXF).
口服FQs之后,在三个时间点 (第1,7,14天) 采集丸组织.
进行了基因病理学 (H&E),免疫组织化学 (COX-2) 和生化分析 (MDA,ADA,ACHE).

主要成果:

诺基诺暴露诱导不同程度的丸退化和增加COX-2表达.
莫西弗洛克萨辛 (MXF) 显示,马隆迪亚尔甲 (MDA) 水平的时间依赖性下降.
氨酸脱氨酶 (ADA) 活性在CIP和LVX时增加,而乙胆酶 (AChE) 水平在LVX和MXF时增加.

结论:

诺基诺衍生物在丸组织上表现出时间依赖的退行性和炎症性作用.
这些发现表明,与FQ使用相关的男性生殖毒性的潜在风险.
需要进一步的研究来阐明FQ诱导的生殖毒性背后的机制.

关键词:

生物化学标记物生物化学标记物在COX-2中,COX-2是最常见的.诺基诺的化.鼠标鼠标鼠标鼠标鼠标测试测试测试测试

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