婴儿和儿童的微量元素的特定年龄和性别的参考间隔:中国林康的一项多中心研究
Junqiang Li1, Zhongguo Chen1, Xuezu Zhang2
1Department of Neonatology, Lincang Maternity and Child Health Hospital, Lincang, China.
Frontiers in pediatrics
|October 15, 2025
概括
本研究为儿童的基本微量元素建立了特定于年龄和性别的参考间隔 (RIs). 这些发现为在儿科健康评估中准确的血液分析提供了关键数据.
科学领域:
- 临床化学 临床化学
- 儿科健康 儿科健康
- 微量元素分析 微量元素分析
背景情况:
- 微量元素的参考间隔 (RIs) 对儿科健康至关重要.
- 现有的RI可能不准确地反映儿童的年龄和性别特异性差异.
- 从三个健康查中心收集数据.
研究的目的:
- 为了确定儿童血液中铜,,,,,铁和的特定年龄和性别的参考间隔 (RIs).
- 开发一个强大的算法来计算这些RI.
- 为实验室提供全球参考.
主要方法:
- 利用了来自3933名儿科门诊患者 (<18岁) 的数据.
- 采用原子吸收光谱法用于微量元素测量.
- 应用分类和回归树 (CART) 和refineR算法用于年龄细分和RI计算,通过Harris-Boyd和Lahti方法验证.
主要成果:
- 六种微量元素 (铜,,,,铁,) 在1个月至18岁的年龄分组中确定的RI.
- 观察到与年龄相关的显著趋势:铜和的减少,随着年龄的增长增加和铁.
- 两性在15岁左右血水平达到峰值,而保持稳定.
结论:
- 在儿童中成功建立了六个关键微量元素的特定年龄和性别的参考间隔.
- 该refineR算法和细分方法为全球实验室提供了可靠的方法.
- 这些RI将有助于准确解释儿科患者的微量元素状况.
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