在快速眼动睡眠期间,使用有针对性的记忆重新激活来解除情感记忆
Viviana Greco1, Tamas A Foldes1, Mahmoud E A Abdellahi1,2
1Psychology Department, Cardiff University Brain Research Imaging Centre, (CUBRIC), Cardiff University, Cardiff, United Kingdom.
Imaging neuroscience (Cambridge, Mass.)
|October 15, 2025
概括
快速眼动睡眠 (REM) 记忆的重新激活减少了大脑和自主性兴奋的负面刺激. 这一发现表明,对于抑郁和焦虑等情绪障碍的潜在治疗应用.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 心理生理学 心理生理学
背景情况:
- 快速眼动 (REM) 睡眠理论上是通过记忆重新激活来处理情绪的.
- 与记忆相关的听觉线索可以触发REM再激活,潜在地减少主观情绪兴奋.
- 需要对REM睡眠期间大脑和自主反应的客观测量.
研究的目的:
- 客观地调查REM睡眠记忆重启对大脑和自主神经系统唤醒的影响.
- 检查REM相关记忆的重新激活如何影响情绪和突出网络中的神经活动.
- 为了将客观的生理变化与主观的兴奋评分相关联.
主要方法:
- 参与者接受了负影音对的初始评分.
- 在REM睡眠期间,使用听觉线索诱导了有针对性的记忆重新激活.
- 使用fMRI测量大脑活动,通过脉冲氧计测量自主反应,编码后48小时测量.
- 收集了睡眠后的主观兴奋评级.
主要成果:
- 快速睡眠记忆的重新激活显著降低了 Salience Network (SN) 中的活性,包括前侧胰岛和背部前侧环状皮层 (dACC).
- 减少的神经反应也被观察到在情绪处理区域,如轨道前皮层,阴茎下环膜和左桃体.
- 在REM睡眠期间的记忆重新激活导致心率减慢 (HRD).
- 主观兴奋在极度令人不安的图像下降,但在不那么令人不安的图像上增加.
结论:
- 快速睡眠记忆的重新激活有效调节与情绪刺激相关的神经和生理反应.
- 研究结果支持REM睡眠在情感记忆处理和情感调节中的作用.
- 这项研究对开发用于情绪和焦虑障碍的新疗法有意义.
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