认知和身体活动与记忆诊所队列中的认知性有关
Diana I Bocancea1,2, Anna C van Loenhoud1,2, Bart Kuijper1,2
1Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam 1081 HV, The Netherlands.
Brain communications
|October 15, 2025
概括
参与认知和身体活动与更好的认知和降低死亡风险有关,特别是在阿尔茨海默病 (AD) 和相关疾病患者中. 过去的认知活动可能会对抗认知衰退提供长期益处.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 像认知和体育活动这样的生活方式因素被认为可以增强大脑对神经退行性疾病的抵抗力.
- 这些活动对阿尔茨海默病 (AD) 和相关疾病的认知结果和大脑变化的确切影响尚不清楚.
研究的目的:
- 在大型记忆诊所队列中调查认知和身体活动与认知功能,大脑缩和临床进展之间的关联.
- 探索这些生活方式因素的潜力,在阿尔茨海默氏病连续性中赋予抗神经退行性.
主要方法:
- 利用阿姆斯特丹痴呆症队列 (ADC) 中4033名个人自我报告的认知和身体活动数据.
- 采用线性模型来比较诊断组 (痴呆症,MCI,SCD) 的活动水平.
- 应用线性混合效应模型和Cox生存模型在AD连续的子集 (n=904) 中,以评估活动对认知,缩,进展和死亡率的影响.
主要成果:
- 具有较高认知和身体活动水平的个体通常在类似的脑缩水平下具有更好的认知功能.
- 当前的认知和身体活动与总样本中死亡风险降低有关.
- 过去的认知活动与死亡风险降低有关,特别是在轻度认知障碍 (MCI) 中,并建议长期认知益处.
结论:
- 对认知和体力活动的更高参与与更好的认知表现和降低死亡率有关,可能提供对神经退行过程的弹性.
- 虽然当前活动的好处可能受到反向因果关系的影响,但过去的认知参与似乎提供了持久的优势,突出了终身认知刺激的重要性.
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