在印度产前妇女中,合免疫和相关风险因素的流行:系统性审查和元分析
Shamee Shastry1, Deepika Chenna1, Soumya Das2
1Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
孕产妇的免疫接种影响到印度2%的孕妇,其中抗D是最常见的. 预防策略中的差距,如抗D预防,需要解决以减少胎儿并发症.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 孕产妇的免疫接种对围产期健康构成重大风险.
- 印度的流行率各不相同,需要进行全面的审查.
- 了解促成因素对于有针对性的干预至关重要.
研究的目的:
- 为了确定印度孕产妇合免疫接种的综合流行率.
- 为了识别与母亲的共免疫接种相关的风险因素.
- 评估目前预防策略的有效性.
主要方法:
- 14项研究 (2011-2023) 的系统综述和元分析.
- 在Scopus,谷歌学者,MEDLINE和CINAHL数据库中进行了搜索.
- 由独立审稿人进行数据提取;用于元分析的二进制随机效应模型.
主要成果:
- 孕产妇合免疫接种的综合流行率为2.0% (95% CI:1.5-2.5).
- 最常见的是抗D抗体 (56.39%),其次是抗D+抗C (10.68%).
- 风险因素包括Rh D阴性血型,多重妊娠状态,输血病史和不良产科病史.
结论:
- 尽管进行了抗D预防,但很大一部分免疫女性具有抗D抗体,这突显了预防缺陷.
- 进一步的研究对于完善干预措施和尽量减少胎儿/新生儿并发症至关重要.
- 抗原匹配红细胞输血可以减少生殖年龄妇女的免疫负担.
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