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聚基-1 odomain 抑制剂的选择性是由一个独特的带结合口袋介导的

Raymundo Nuñez1, Karina L Bursch1, Savannah J Makowski1

  • 1Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.

ACS medicinal chemistry letters
|October 15, 2025
PubMed
概括

选择性多基-1 (PBRM1) 抑制剂提供了新的癌症治疗潜力. 在癌症模型中,PBRM1中独特的氨酸残留是选择性抑制剂结合和疗效的关键.

关键词:
聚胺-1 聚胺-1 是一种在X射线晶体学.类蛋白质是一种类蛋白质.抑制剂选择性的抑制剂选择性异热定位热量计 异热定位热量计突变发生的突变发生.

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