在接受胰腺二切除术的患者中,肉类症作为预后标志物:更新的元分析
Jie He1,2,3, Jia Li1,2,3, Jia Liu1,4
1School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Frontiers in oncology
|October 15, 2025
概括
肌肉损失的状况 - - 萨尔科佩尼亚 - - 在接受胰腺双管切除术 (PD) 的患者中很常见. 这项研究发现,sarcopenia显著增加并发症,死亡率的风险,并降低了PD后的生存率.
科学领域:
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
- 老年病的医生 老年病的医生
背景情况:
- 在接受胰腺双管切除术 (PD) 的患者中,肉症很常见.
- 讨论了萨科佩尼亚对PD结果的影响.
- 这一元分析评估了sarcopenia作为PD患者的预后指标.
研究的目的:
- 为了评估在PD前患者中类病的患病率.
- 为了确定萨尔科佩尼亚和术后并发症之间的关联.
- 评估萨科佩尼亚对PD后存活率的影响.
主要方法:
- 在多个数据库 (PubMed,EMBASE等) 的系统文献搜索. 在2025年3月之前.
- 包括30篇文章与5323名参与者.
- 使用Stata版本11.0进行统计分析,计算聚合流行率,赔率比率 (ORs) 和危险比率 (HRs).
主要成果:
- 在PD前的肉类的患病率为35%.
- 石症与较高的重大并发症风险 (OR=1.84),POPF (OR=1.47),POBF (OR=1.53) 和死亡率 (OR=3.52) 有显著的相关性.
- 患有肉类症的患者的无病存活率 (HR=2.28) 和整体存活率 (HR=3.15) 较差.
结论:
- 在PD患者中,很大一部分患有肉症.
- 萨科佩尼亚与术后并发症,死亡率和生存结果较差的增加有关.
- 建议进一步研究使用更严格的萨尔科佩尼亚定义.
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