在一个主要的COVID-19爆发浪潮中,精液参数的时间变化:使用流行病学时间窗口进行回顾性队列研究
Hai Wang1, Xianjue Zheng1, Haojie Pan1
1Center for Reproductive Medicine, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, Wenzhou, China.
Frontiers in reproductive health
|October 15, 2025
概括
男性的精液质量,包括精子度和运动性,在COVID-19重大爆发期间显著下降. 疫情爆发后,精液参数恢复到正常水平,表明精子功能有弹性.
科学领域:
- 生殖健康 生殖健康
- 流行病学 流行病学
- 病毒学 病毒学
背景情况:
- 由于COVID-19的流行,人们对其对男性生殖健康的潜在影响感到担忧.
- 了解病毒爆发对精液质量的影响对于公共卫生和生育管理至关重要.
研究的目的:
- 为了调查男性精液质量参数在重大COVID-19爆发浪潮之前,期间和之后的时间变化.
- 评估区域性COVID-19疫情对精子度,运动性,氨酸活性和DNA碎片化的影响.
主要方法:
- 一项回顾性队列研究分析了2022年6月至2023年6月的精液样本.
- 根据区域COVID-19数据,参与者被分为爆发前,爆发高峰和爆发后阶段.
- 传统的精液参数,精子青活性和精子DNA碎片化指数 (DFI) 在不同组之间进行了比较.
主要成果:
- 在COVID-19爆发高峰期间,与爆发前后相比,精子度和渐进性运动率显著降低.
- 在疫情爆发后,精液参数恢复到疫情爆发前的水平.
- 在不同爆发阶段,精子青素活性和DFI没有显著变化.
结论:
- 一个主要的COVID-19疫情浪潮与男性精液质量的显著暂时下降有关.
- 精液质量恢复到基线水平在峰值爆发后的三个月内.
- 关键的精子功能生物标志物,如阿克罗辛活性和DNA完整性,在疫情爆发期间表现出弹性.
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