在肝硬化患者中使用囊素C和血清肌素对功能进行比较评估:一项前性横截面研究
Anila Bibi1, Sadia Rehman2, Muhammad Farhan3
1Department of Biochemistry Jinnah Sindh Medical University Karachi Pakistan.
Health science reports
|October 15, 2025
概括
血清肌素 (Cr) 和囊素C (Cys) 水平进行了比较,以评估肝硬化患者的功能. 单独或与Cr一起使用的cystatin C,随着肝硬化严重程度的增加,提供了更敏感的功能障碍评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 生物标志物研究 生物标志物研究
背景情况:
- 在肝硬化患者中评估功能是具有挑战性的,因为血清肌素等传统生物标志物的局限性.
- 现有的生物标志物可能不准确地反映肝病不同阶段功能障碍的真实程度.
研究的目的:
- 为了比较血清肌素 (Cr) 和囊素C (Cys) 的诊断效用,用于评估肝硬化患者的功能.
- 使用这些生物标志物,评估肝硬化严重程度不同阶段的功能.
主要方法:
- 120名参与者 (30名健康对照组,90名肝硬化患者) 的前性横截面研究.
- 测量血清Cr和Cys,使用CKD-EPI 2021方程 (Cr,Cys,Cr-Cys) 估计的淋巴膜过率 (eGFR).
- 根据eGFR计算的Cr/Cys比率和基于eGFR的慢性病 (CKD) 阶段的分类.
主要成果:
- 血清Cr在肝硬化患者中升高,但不因疾病严重程度而异,而Cys随着肝硬化进展而逐渐增加 (p < 0.001).
- 随着肝硬化严重程度的增加,Cr/Cys比率下降,这表明生物标志物不一致.
- 基于Cys和联合Cr-Cys的eGFR方程显示了Child-Pugh类的逐步下降,比基于Cr的方程识别了更先进的功能障碍.
结论:
- 在CKD-EPI方程式中,单独或与肌氨酸结合使用的cystatin C可在肝硬化严重程度增加的患者中提供更敏感的功能障碍评估.
- 这表明囊素C是监测肝病患者脏健康的宝贵工具.
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