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在肺癌中重新编程免疫微环境

Kai Chen^1,2,3, Linqi Luo⁴, Yong Li²

¹Department of Laboratory Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, China.

Frontiers in immunology

|October 15, 2025

概括

肺癌的进展涉及一个复杂的瘤微环境 (TME). 重新编程这种免疫抑制性TME的策略对于提高肺癌患者免疫疗法的有效性至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

肺癌是全球癌症死亡的主要原因之一.
瘤微环境 (TME) 显著影响肺癌的进展和免疫规避.
在TME中的关键免疫细胞,如巨细胞和髓状细胞衍生的抑制细胞,促进免疫抑制.

研究的目的:

审查免疫细胞子集在肺癌中的功能作用.
突出新兴的重编程免疫抑制TME的策略.
讨论提高对肺癌免疫疗法的反应能力.

主要方法:

在肺癌中免疫细胞功能的文献综述.
对TME内的免疫抑制机制的分析.
探索针对TME的新型治疗策略.

主要成果:

多种免疫细胞 (T细胞,B细胞,NK细胞,TAMs,MDSCs) 在肺癌免疫中起着至关重要的作用.
TAMs和MDSCs通过细胞因子和代谢干扰促进免疫抑制.
高M2极化TAM和MDSC与不良预后和治疗抵抗有关.

结论:

免疫抑制性TME限制了当前肺癌免疫疗法的有效性.
重新编程TME对于改善治疗结果至关重要.
新兴的策略旨在克服TME介导的免疫抑制,以增强免疫治疗反应.

关键词:

在MDSC中,MDSC是MDSC.这就是TAMAMTAM.免疫逃避免疫逃避免疫疗法免疫疗法肺癌是一种肺癌.瘤微环境是一个微环境.

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