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一个灵活的系统分析管道,用于阐明瘤微环境中的空间关系,与细胞表型和患者级特征相关

Gabriel F Hanson1, Kate A Goundry1, Remziye E Wessel1

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.

Frontiers in immunology
|October 15, 2025
PubMed
概括

分析瘤中的空间细胞组织揭示了对癌症进展和患者结果的关键见解. 这个计算管道确定了预测细胞状态和非小细胞肺癌临床表型的空间关系.

关键词:
在 NK 细胞中, NK 细胞是最重要的.一个T细胞细胞.免疫相互作用 免疫相互作用空间生物学空间生物学空间蛋白质组学 空间蛋白质组学监督机器学习是指监督机器学习.系统免疫学 免疫学瘤与免疫细胞的相互作用

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...