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叶酸受体β在激活的巨细胞中执行免疫检查点功能

Fenghua Zhang1, Md Yusuf Al-Amin1,2, Sagar Utturkar3

  • 1Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States.

Frontiers in immunology
|October 15, 2025
PubMed
概括

叶酸受体β (FRβ) 作为免疫检查点,调节髓状细胞功能. 在小鼠中删除FRβ可以通过增强促炎反应来减少瘤生长和自身免疫症状.

关键词:
骨髓干细胞抑制细胞 (MDSCs) 是一种由骨髓干细胞衍生的抑制细胞.癌症免疫疗法免疫疗法叶酸受体β (FRβ,Folr2) 是一种免疫检查点是一个检查点.巨细胞的两极分化巨细胞是什么?巨细胞是什么?瘤微环境是一个微环境.与瘤相关的巨细胞 (TAMs)

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