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通过3D脚手架微型架构设计巨细胞反应.

Chiara Martinelli1, Srijan Chakraborty1, Giovanni Buccioli1

  • 1Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza L. da Vinci, 32, 20133, Milan, Italy.

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概括

定制3D生物材料支架孔径影响巨细胞反应,平衡炎症用于组织再生和药物查应用.

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科学领域:

  • 生物材料科学 生物材料科学
  • 免疫学 免疫学 免疫学
  • 组织工程是组织工程.

背景情况:

  • 生物材料植入引发异物反应,涉及巨细胞两极分化成M1 (促炎) 或M2 (抗炎) 类型的表型.
  • 控制巨细胞的行为对于组织再生至关重要,人们对定制生物材料物理性质越来越感兴趣.
  • 3D微结构在调节巨细胞行为和免疫反应中的作用尚不清楚.

研究的目的:

  • 为了研究3D支架的微观结构,特别是孔径大小,如何影响巨细胞的行为和两极分化.
  • 确定3D微结构是否可以被设计为促进组织工程和药物开发所需的免疫反应.

主要方法:

  • 使用双光子聚合,制造具有明显的大 (50 × 50 × 20 μm3) 和小 (15 × 15 × 15 μm3) 孔的3D支架.
  • 评估巨细胞骨组织和新陈代谢活动对支架的反应.
  • 在联合支架和化学刺激下评估巨细胞极化标记物 (Arg1和iNOS).

主要成果:

  • 大和小的毛孔支架都影响了巨细胞骨组织和代谢活动.
  • 只有脚手架在免疫学上是惰性的,不会诱导自发的巨细胞两极分化.
  • 在与化学刺激相结合时,大孔略微提高了抗炎性Arg1,而小孔显著增加了促炎性iNOS表达.

结论:

  • 3D微观结构可以对巨细胞的行为提供可调节的控制,这与固有的材料特性不同.
  • 精确设计的3D支架可以平衡亲和抗炎性巨细胞表型.
  • 这些发现为*in vivo*组织工程中的3D支架打开了道路,以防止纤维化和*in vitro*平台用于抗炎药物查.