副心脂肪组织:一个潜在的目标,以改善左心室透功能障碍
Chun-Qiong Ran1,2,3, Wen-Tao He1,2,3
1Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China.
Reviews in cardiovascular medicine
|October 15, 2025
概括
心上脂肪组织 (EAT) 的增加与左心室扩张性功能障碍 (LVDD) 有关. 通过各种干预措施减少EAT可能会改善透缩功能,为心力衰竭预防提供新的治疗途径.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 生理学 生理学 生理学
背景情况:
- 左心室扩张功能障碍 (LVDD) 是心力衰竭的前体,显著影响生活质量和死亡率.
- 准确的诊断和治疗LVDD需要深入了解其潜在的发病因子.
- 心声和心磁共振是评估左心室扩张功能的关键成像技术.
研究的目的:
- 审查LVDD临床评估的最新进展.
- 阐明心上脂肪组织 (EAT) 在LVDD中的病理生理作用.
- 探索针对LVDD管理的ET的治疗潜力.
主要方法:
- 对最近关于LVDD和EAT的研究进行文献综述.
- 在各种条件下分析了与LVDD相关的临床数据.
- 针对EAT的治疗干预措施的评估及其对扩张功能的影响.
主要成果:
- 增加的EAT在各种临床环境中始终与LVDD相关,包括高血压,冠状动脉疾病,糖尿病和肥胖症.
- 旨在减少EAT的干预措施,如药物,生活方式变化和减肥手术,在改善腹参数方面表现有前途.
- 这些减少EAT的策略似乎同时增强了扩张功能恢复.
结论:
- 胸前脂肪组织在LVDD的病理生理学中起着重要作用.
- 向减少EAT是一个有希望的治疗策略,用于管理LVDD,并可能预防心力衰竭的进展.
- 对以EAT为重点的干预措施的进一步研究可能会改善腹功能障碍患者的临床结果.
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