加快的生物衰老调解了老年人牙周病和认知功能之间的关联
Xiang Qi1, Huabin Luo2, Zhijing Xu1
1Rory Meyers College of Nursing, New York University, New York, New York, United States.
Innovation in aging
|October 15, 2025
概括
加快的生物衰老部分解释了牙周病与老年人认知能力下降之间的联系. 这一发现支持一种基于老年科学的机制,即口腔炎通过衰老过程影响认知功能.
科学领域:
- 地质科学是地球科学.
- 口腔健康 口腔健康
- 认知老龄化 认知老龄化
背景情况:
- 牙周炎是老年人常见的牙疾病,与认知能力下降有关.
- 连接牙周炎和认知功能的潜在机制仍然不清楚.
- 老年科学假设表明,基本的衰老过程驱动着与年龄相关的疾病.
研究的目的:
- 调查加速生物衰老是否调解了60岁及以上成年人牙周病和认知功能之间的关联.
- 探索一种基于老年科学的新机制,将口腔炎与认知衰退联系起来.
主要方法:
- 从国家健康和营养检查调查 (1999-2002) 中对1950名老年人 (≥60岁) 的数据进行分析.
- 牙周状况 (CAL,PD) 和认知能力 (DSST) 的临床评估.
- 使用Klemera-Doubal方法 (KDM) 和表型年龄 (PhenoAge) 算法量化生物衰老,然后进行调解分析.
主要成果:
- 牙周炎与较差的认知功能 (DSST) 和更高的生物衰老加速 (BAA) 显著相关,使用KDM和PhenoAge.
- 增加的临床依恋丧失 (CAL) 与较低的DSST得分和更高的BAA相关.
- 调解分析表明,KDM-BAA和PhenoAge加速解释了牙周病和认知功能之间的关系的5.7%-15.1%.
结论:
- 加快的生物衰老部分介绍了牙周病和认知功能之间的联系.
- 这些发现支持基于老年科学的机制,将口腔炎,全身衰老和认知衰退联系起来.
- 针对口腔健康的干预措施可能有助于缓解衰老和保持认知功能.
相关概念视频
Aging
600
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
600
Cognitive Development During Adulthood
772
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
772
Pharmacodynamics in Geriatric Patients: Effects of Age
187
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
187
The Effect of Aging on Tissues
3.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.3K
Teeth
1.6K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.6K
Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K


