乙醇提取物Carpesium abrotanoides通过抑制炎症和亡来缓解硫酸诱导的性结肠炎
Aejin Kim1,2, So Yeon Kim3, Kyuhyung Jo1
1KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Frontiers in pharmacology
|October 15, 2025
概括
卡尔佩西 (Carpesium abrotanoides) 提取物 (CAE) 通过减少炎症和亡,显示出对性结肠炎 (UC) 治疗的前景. 这种天然化合物有助于维持肠道屏障的完整性,为UC提供了潜在的治疗方法.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 传统上使用 *Carpesium abrotanoides * 治疗炎症疾病.
- 缺乏关于其在性结肠炎 (UC) 中有效性的科学证据.
研究的目的:
- 研究 *C. abrotanoides* 提取物 (CAE) 在治疗UC中的保护机制.
- 评估CAE作为肠道炎症的天然剂的治疗潜力.
主要方法:
- 使用超高性能液态色谱识别CAE组件.
- 网络药理学和分子对接,以预测目标和途径.
- 在硫酸德克斯诱导的UC小鼠模型中评估CAE疗效.
主要成果:
- CAE含有基酸,kaempferol 3-O-rhamnoside和dikaffeoylquinic 酸.这些酸在咖啡因中含有基酸,卡恩菲罗尔3-O-rhamnoside和dikaffeoylquinic 酸.
- 这些化合物向涉及TNF-α,IL-6,IL-1β,caspase-3和Bcl-2的炎症和亡途径.
- CAE减少了疾病活动,结肠损伤和炎症标志物,同时保持了肠道屏障的完整性和调节了亡.
结论:
- 在UC模型中,CAE显示出显著的抗炎和抗亡作用.
- CAE有助于保持肠道屏障的完整性,这对于治疗大肠炎至关重要.
- 这些发现支持CAE作为性结肠炎的潜在多目标天然治疗剂.
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