早期冠状动脉疾病患者的性别差异
Thamir M Al-Khlaiwi1, Syed S Habib1, Hessah F Alshammari2
1Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Journal of family medicine and primary care
|October 15, 2025
概括
根据Gensini得分,男性患者表现出更严重的冠状动脉疾病,而女性则显示出更多的前置ST升高. 左主动脉封闭也更常见于早发冠状动脉疾病 (PCAD) 的男性.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 医学研究 医学研究
背景情况:
- 早期冠状动脉疾病 (PCAD) 影响年轻人,在诊断和管理方面提出了独特的挑战.
- 了解PCAD表现的性别差异对于量身定制的临床方法至关重要.
- 现有的研究突出了潜在的差异,需要进一步调查性别之间的疾病严重程度和表现模式.
研究的目的:
- 研究和比较早发性冠状动脉疾病 (PCAD) 严重程度和临床表现的性别特异性差异.
- 分析人口统计,生物标志物和血管学数据,以确定男性和女性PCAD患者的不同模式.
- 评估性别与特定冠状动脉疾病标志物 (如Gensini和血管分数) 之间的相关性.
主要方法:
- 2015年至2022年间,哈立德国王大学医院 (KKUH) 的患者数据的回顾性分析.
- 包括PCAD患者的人口统计细节,化学生物标志物和冠状动脉血管学发现.
- 使用血管图报告计算Gensini和血管分数以量化疾病严重程度.
主要成果:
- 与女性相比 (53.5%对39.5%,P=0.021),男性的根西尼分数 (>39) 显著更高,表明疾病更严重.
- 与男性相比,女性在心电图 (ECG) 上更频繁地出现前侧ST升高.
- 虽然两种性别的两种或三种血管封闭率相似 (57.4%的男性对58.2%的女性,P=0.150),但左主动脉封闭在男性中更为普遍 (约. 8%) 超过女性 (3.5%).
结论:
- 患有PCAD的男性患者通常具有更严重的冠状动脉疾病,由更高的根西尼得分和更高的左主动脉封闭发生率表明.
- 电心图发现,女性PCAD患者前侧ST升高的患病率较高.
- 年龄分布显示,PCAD的高峰发病率在45-50岁之间,女性的影响更明显,而年轻年龄组的男性患病率更高.
更多相关视频
05:41Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
Published on: December 16, 2022
4.2K
13:10Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
Published on: April 24, 2017
19.1K
相关概念视频
01:30Coronary Artery Disease I: Introduction
843
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
843
01:30Coronary Artery Disease III: Clinical Manifestations
295
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
295
01:30Acute Coronary Syndrome III: Diagnostic Studies
190
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
190
01:26Coronary Artery Disease II: Pathophysiology
332
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
332
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
323
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
323
01:30Acute Coronary Syndrome I: Introduction
690
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
690