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在VEGF和KDR基因中多形态的作用在骨质疏松症易感性中:系统性综述

Amanda Dos Santos Cavalcanti¹, Jéssica Vilarinho Cardoso², Verônica Aran Ponte³

¹. Instituto Nacional de Traumatologia e Ortopedia (INTO), Divisao de Pesquisa, Rio de Janeiro, RJ, Brazil.

Acta ortopedica brasileira

|October 15, 2025

概括

血管内皮生长因子 (VEGF) 的遗传变异可能会影响骨肉瘤风险. 这次审查发现了中国人群中特定的VEGF多态和骨肉瘤易感性之间的关联,但没有研究KDR基因变异.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

骨髓瘤是儿童和青少年常见的一种侵袭性骨瘤.
由血管内皮生长因子 (VEGF) 和其受体 (KDR) 驱动的瘤血管生成对于骨髓瘤的发展至关重要.
在VEGF和KDR基因中常见的遗传多态化与骨髓瘤风险之间的关联尚未得到充分证实.

研究的目的:

系统地审查观察性研究,评估VEGF和KDR基因多态化与骨肉瘤易感性之间的关联.
综合目前关于这些遗传变异在骨髓瘤发育中的作用的证据.

主要方法:

在PubMed,Medline,Lilacs和SciELO进行了系统的文献搜索,直到2024年4月.
包括来自中国人口的八项病例控制研究 (1,681例,2,049例)
分析了六种VEGF多态;在任何包括的研究中都没有评估KDR基因多态.

主要成果:

特定的VEGF多态 (rs699947,rs2010963,rs3025039,rs833061) 显示出与增加骨髓瘤易感性的潜在关联.
对于VEGF多态体rs1570360和rs10434.4没有发现任何显著的关联.
没有研究研究KDR基因多态性与骨髓瘤风险相关.

结论:

某些VEGF基因多态可能会导致中国人群中骨髓瘤敏感性.
在骨髓瘤中KDR基因多态的作用仍未得到研究.
需要对包括巴西人在内的不同族群进行进一步的研究,以证实这些发现并探索预后影响.

关键词:

血管新生的产生.遗传的多态化遗传的多态化骨质肉瘤骨质肉瘤是什么系统审查是系统的审查.在VEGF中,VEGF是VEGF.

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