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Updated: Jan 15, 2026

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特定于B细胞的Wwox删除促进了髓瘤模型中的血性瘤发育和促炎特征

Tabish Hussain1, Matthew D Bramble1, Bin Liu1

  • 1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX.

Blood neoplasia
|October 15, 2025
PubMed
概括

在B细胞中失去WWOX (沃克-沃伯格综合征同源) 会加速癌症的进展. 在小鼠中,同时删除WWOX和MYC激活导致了侵袭性淋巴瘤和血细胞瘤,突出显示WWOX.

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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