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在精神性厌食症住院治疗期间体重轨迹:动态时间曲线分析

Marianne Tokic¹, Georg Halbeisen², Karsten Braks³

¹Department of Medical Informatics, Biometrics and Epidemiology, Ruhr-University Bochum, Bochum, Germany.

The International journal of eating disorders

|October 15, 2025

概括

这项研究在使用动态时间扭曲的精神性厌食症 (AN) 患者中确定了四种不同的体重增加轨迹. 这些概况预测治疗结果,帮助个性化AN恢复计划.

科学领域:

精神病学和行为科学
数据科学和分析数据科学和分析

背景情况:

恢复体重对于治疗神经性厌食症 (AN) 是至关重要的.
之前的研究发现了体重增加模式和AN治疗结果之间的联系,但缺乏对个人资料分类的共识.
体重增加概况的异质性可能来自恢复过程中的时间变化或"扭曲".

研究的目的:

在住院治疗期间确定AN患者的明显体重增加轨迹.
应用一种新的非参数方法,考虑时间扭曲 (扭曲),以分析体重增加模式.
为了确定确定体重增加概况是否能预测治疗结果.

主要方法:

在518名AN患者的样本上使用了带有动态时间变形 (DTW) 的时间序列聚类.
使用人体内体重指数增长 (Δ BMI) 作为集群识别的主要指标.
通过入院心理病理学得分来描述已识别的集群,并分析它们与临床结果变化之间的关联.

主要成果:

确定了四个不同的体重增加集群:初始增加 (n=76),持续增加 (n=329),初始损失和恢复 (n=70) 和体重减轻 (n=43).
集群在入院BMI,精神病理学得分和治疗持续时间方面有显著差异.
发现集群分配可以预测治疗结果,这表明这些配置文件的临床相关性.

结论:

一种基于DTW的新方法在一个大型AN样本中确定了预测结果的体重增加概况.
与之前的研究相比,这些发现提供了对体重增加异质性的更细致的理解.
这些详细的配置文件可以为个性化AN治疗策略提供信息,并优化资源配置.

关键词:

神经性厌食症是一种神经性厌食症.动态时间扭曲.住院治疗住院治疗心理治疗是一种心理治疗.体重变化体重变化

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