关于脑疾病的复杂网络视角
David Papo1,2, Javier M Buldú3
1Department of Neuroscience and Rehabilitation, Section of Physiology, University of Ferrara, Via Fossato di Mortara, 19, Ferrara, 44121, Italy.
Biological reviews of the Cambridge Philosophical Society
|October 15, 2025
概括
大脑网络结构是功能和功能障碍的关键. 了解这种"网络性"可以揭示大脑病理,脆弱性和恢复潜力.
科学领域:
- 神经科学是一个神经科学.
- 网络科学 网络科学
- 计算生物学 计算生物学
背景情况:
- 复杂的网络结构在大脑解剖学和动态学中越来越被认可.
- 这些网络结构在大脑功能障碍和病理学中的作用仍然不清楚.
- 通过网络镜头来定义大脑疾病是一个新兴的研究领域.
研究的目的:
- 探索如何复杂的网络表示可以表征大脑病理.
- 评估网络结构对脑疾病的脆弱性和恢复的影响.
- 研究疾病定义,功能定义和相关网络属性之间的关系.
主要方法:
- 大脑网络理论的概念分析.
- 讨论与大脑功能和功能障碍相关的网络特性.
- 定义大脑病态为"网络疾病"的框架.
主要成果:
- 网络结构显著影响大脑功能和功能障碍.
- 疾病和功能的定义决定了特定网络特性的重要性.
- 网络视角为个人易感性和恢复轨迹提供了洞察力.
结论:
- 使用网络科学来描述大脑病理,可以阐明疾病机制.
- 了解大脑"网络性"对评估和治疗神经系统疾病有潜在的临床影响.
- 这种方法提高了我们对功能性大脑活动及其与病理学的关系的理解.
相关概念视频
Organization of the Brain
2.3K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.3K
Disorders of the Nervous Tissue
2.5K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.5K
The Blood-brain Barrier
52.3K
Overview
52.3K
Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Neural Regulation
43.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.1K
Neuroplasticity
1.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.6K


