相关实验视频
Updated: Jan 15, 2026
10:36
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
20.6K
从微生物群到代谢学:Bifidobacterium infantis YLGB-1496如何保护新生儿免受死性肠球炎的侵害
Jingyu Li1, Hanglian Lan2,3, Yue Liu1
1School of Food and Health, Beijing Technology and Business University, Beijing 100048, China. zhangming@th.btbu.edu.cn.
Food & function
|October 15, 2025
概括
双细菌长子物种 双菌长子物种 infantis YLGB-1496通过增加有益细菌和改变托代谢,减少炎症来保护新生小鼠免受瘤性肠球炎 (NEC) 的侵害.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 双杆菌物种对于婴儿肠道健康至关重要.
- 双菌的抗炎作用的机制尚未完全理解.
- 死性肠结肠炎 (NEC) 是新生儿的一种严重的肠病.
研究的目的:
- 为了研究Bifidobacterium longum亚种的保护作用. 在小鼠模型中,infantis YLGB-1496 (GB1496) 对抗NEC.
- 阐明潜在的机制,包括微生物群变化和代谢物变化.
主要方法:
- 在新生小鼠中的NEC实验模型.
- GB1496.6.的口服使用.
- 分析肠道微生物群的组成.
- 血清非向的代谢组.
- 测量托尔类受体4 (TLR-4) 介导的炎症反应.
主要成果:
- GB1496 显著降低了NEC小鼠的死亡率和肠道损伤.
- GB1496增加了乳酸菌和双菌的丰富性.
- 血清酸代谢物 (例如,英多尔-3-酸) 的显著改变被观察到.
- GB1496降低调节的TLR-4介导的炎症反应.
结论:
- 双细菌长子物种 双菌长子物种 婴儿用品YLGB-1496提供了对NEC的保护.
- 保护作用与Bifidobacterium和Lactobacillus丰富度的增加有关.
- 托芬代谢物改变,可能激活AHR通路,有助于抗炎作用.
相关概念视频
01:29Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
01:23Anatomy of the Intestines
86.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.7K
01:27Bacterial Phylum Firmicutes
923
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
923