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炎症性肠道疾病中支气管切除症的患病率和危险因素:一个基于胸部CT的病例控制研究
Jiaqi Ren1, Lina Sun1, Meijiao Li2
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Research Center for Chronic Airway Diseases, Peking University Health Science Center, Beijing, China.
Expert review of respiratory medicine
|October 15, 2025
概括
超过三分之一的炎症性肠病 (IBD) 患者患有未被诊断的支气管切开症,往往无症状. 常规的胸部HRCT查是建议在IBD患者的早期检测.
科学领域:
- 胃肠病学和肺病学 胃肠病学和肺病学
- 医疗成像医学成像
- 炎症性肠道疾病研究研究
背景情况:
- 炎症性肠病 (IBD) 涵盖了胃肠道的慢性炎症状况.
- 支气管切除症是一种慢性肺部疾病,可以与IBD共存,但其在这个人群中的患病率和特征尚未确定.
- 确定IBD和支气管病变之间的联系对于全面的患者管理至关重要.
研究的目的:
- 为了确定炎症性肠病 (IBD) 患者中支气管切除症的患病率.
- 在IBD患者中描述支气管切除症的临床和成像特征.
- 为了确定与IBD中支气管切除症的发展相关的风险因素.
主要方法:
- 从2020年1月到2022年7月,对429名IBD患者进行了回顾性队列研究.
- 胸部的高分辨率计算机断层扫描 (HRCT) 用于评估支气管切除症.
- 分析了临床数据和成像研究结果,以比较患有支气管切除症和没有支气管切除症的患者.
主要成果:
- 34.5%的IBD患者表现出胸部HRCT上的支气管切开.
- 常见的成像发现包括多叶囊参与,中央占主导地位,圆柱形支气管支气管和轻度严重性.
- 在IBD中支气管切除症的独立风险因素是发病年龄≥35岁,免疫抑制剂治疗,ESR升高 (>20 mm/h) 和阳性ASCA.
结论:
- 显著比例的IBD患者出现支气管切除症,通常是亚临床的.
- 在IBD中,支气管切除症的温和和中心性质可能导致诊断不足.
- 应考虑对IBD患者进行常规胸部HRCT查,以检测支气管切除.
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